✦ LIBER ✦

Common genetic variants in pre-microRNAs were associated with increased risk of breast cancer in Chinese women

✍ Scribed by Zhibin Hu; Jie Liang; Zhanwei Wang; Tian Tian; Xiaoyi Zhou; Jiaping Chen; Ruifen Miao; Yan Wang; Xinru Wang; Hongbing Shen

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 139 KB
Volume: 30
Category: Article
ISSN: 1059-7794
DOI: 10.1002/humu.20837

No coin nor oath required. For personal study only.

✦ Synopsis

Small, noncoding RNA molecules, called microRNAs (miRNAs), are thought to function as either tumor suppressors or oncogenes. Common singlenucleotide polymorphisms (SNPs) in miRNAs may change their property through altering miRNA expression and/or maturation, and thus they may have an effect on thousands of target mRNAs, resulting in diverse functional consequences. However, it remains largely unknown whether miRNA SNPs may alter cancer susceptibility. We evaluated the associations of selected four SNPs (rs2910164, rs2292832, rs11614913, and rs3746444) in pre-miRNAs (hsa-mir-146a, hsa-mir-149, hsa-mir-196a2, and hsa-mir-499) with breast cancer risk in a case-control study of 1,009 breast cancer cases and 1,093 cancer-free controls in a population of Chinese women and we found that hsa-mir-196a2 rs11614913:T4C and hsa-mir-499 rs3746444:A4G variant genotypes were associated with significantly increased risks of breast cancer (odds ratio [OR], 1.23; 95% confidence interval [CI], 1.02-1.48 for rs11614913:T4C; and OR, 1.25; 95% CI, 1.02-1.51 for rs3746444:A4G in a dominant genetic model) in a dose-effect manner (P for trend was 0.010 and 0.037, respectively). These findings suggest, for the first time, that common SNPs in miRNAs may contribute to breast cancer susceptibility. Further functional characterization of miRNA SNPs and their influences on target mRNAs may provide underlying mechanisms for the observed associations and disease etiology.

📜 SIMILAR VOLUMES

Variant genotypes of CDKN1A and CDKN1B a

Variant genotypes of CDKN1A and CDKN1B are associated with an increased risk of breast cancer in Chinese women

✍ Hongxia Ma; Guangfu Jin; Zhibin Hu; Xiangjun Zhai; Wensen Chen; Shui Wang; Xuech 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 105 KB 👁 1 views

## Abstract p21^Cip1^ and p27^Kip1^ are cyclin‐dependent kinase inhibitors, which can arrest cell proliferation and serve as tumor suppressors. Reduced protein expression of p21^Cip1^ and p27^Kip1^ was frequently observed in a subset of cancers, including breast cancer. In this study, we hypothesiz

Functional variants in the promoter of i

Functional variants in the promoter of interleukin-1β are associated with an increased risk of breast cancer: A case-control analysis in a Chinese population

✍ Jiyong Liu; Xiangjun Zhai; Guangfu Jin; Zhibin Hu; Shui Wang; Xuechen Wang; Jian 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 91 KB

## Abstract Interleukin 1β (IL‐1β) is a multifunctional cytokine that upregulates the inflammatory response, and participates in carcinogenesis, malignant transformation, tumor growth, invasion and metastasis. Two potentially functional polymorphisms (T‐31C and C‐511T) in the __IL‐1__β gene promote

Association between N-acetyltransferase

Association between N-acetyltransferase 2 (NAT2) genetic polymorphism and development of breast cancer in post-menopausal Chinese women in Taiwan, an area of great increase in breast cancer incidence

✍ Chiun-Sheng Huang; Herng-Der Chern; Chen-Yang Shen; Su-Ming Hsu; King-Jen Chang 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 82 KB 👁 2 views

The incidence of breast cancer has increased greatly in Taiwan over the past 2 decades. Increased exposure to environmental carcinogens, including aryl aromatic amines, as a result of the economic boom, is suspected to be one factor contributing to this increase. The enzyme N-acetyltransferase 2 (NA