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Common fragile sites and human cancer: A study on lymphocytes from neuroblastoma patients

✍ Scribed by Patrizia Vernole; Bruna Tedeschi; Daniela Caporossi; Benedetto Nicoletti


Book ID
119103805
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
654 KB
Volume
36
Category
Article
ISSN
0165-4608

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Chromosomal fragile sites FRA3B and FRA1
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## Abstract It has been suggested that common fragile sites (cFSs) are related to cancer development. This appears to be the case for FRA3B and FRA16D, localized in two tumor‐suppressor genes (__FHIT__ and __WWOX__, respectively) that are altered by deletions or loss of heterozygosity (LOH) in many