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Common expression of estrogen receptor type A and its gene targets in proliferating breast epithelial cells

✍ Scribed by C. Dimitrakakis; E. Lymberopoulos; A. Tsigginou; A. Antsaklis


Book ID
119597918
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
61 KB
Volume
6
Category
Article
ISSN
1359-6349

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## Abstract The cyclin‐dependent kinase inhibitor protein p21^Waf1/Cip1^ is a potent tumor suppressor. Here, we demonstrate that estradiol regulates the p21^Waf1/Cip1^ gene. Estradiol induces p21^Waf1/Cip1^ mRNA expression within 30–60 min independent of new protein synthesis in the estrogen recept