Common excipients impair detection of protein aggregates during sedimentation velocity analytical ultracentrifugation

Detection of protein aggregates by sedim

Detection of protein aggregates by sedimentation velocity analytical ultracentrifugation (SV-AUC): Sources of variability and their relative importance

✍ Kelly K. Arthur; John P. Gabrielson; Brent S. Kendrick; Michael R. Stoner 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 305 KB

Sedimentation velocity analytical ultracentrifugation (SV-AUC) has found application in the biopharmaceutical industry as a method of detecting and quantifying protein aggregates. While the technique offers several advantages (i.e., matrix-free separation and minimal sample handling), its results ex