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Common Evolutionary Origin of α2-macroglobulin and Complement Components C3 and C4

✍ Scribed by Lars Sottrup-Jensen, Terrence M. Stepanik, Torsten Kristensen, Peter B. Lønblad, Claire M. Jones, Diane M. Wierzbicki, Staffan Magnusson, Horst Domdey, Rick A. Wetsel, Åke Lundwall, Brian F. Tack and Georg H. Fey


Book ID
123631386
Publisher
National Academy of Sciences
Year
1985
Tongue
English
Weight
825 KB
Volume
82
Category
Article
ISSN
0027-8424

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The effect of cadralazine and its active metabolite CGP 22639 on the covalent binding reaction of C4 and C3 has been studied. Trypsin-Sepharose was used to activate radio-labelled C3 and C4 and binding of the radio-labelled protein to the trypsin-Sepharose was measured. Cadralazine inhibited 50% of