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Common clonal chromosome aberrations in cytokine-dependent continuous human T-lymphocyte cell lines

✍ Scribed by Keld Kaltoft; Birgit Holm Hansen; Charlotte B. Pedersen; Søren Pedersen; Kristian Thestrup-Pedersen

Book ID: 113253589
Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 341 KB
Volume: 85
Category: Article
ISSN: 0165-4608
DOI: 10.1016/0165-4608(95)00118-2

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## Abstract ## Background X‐linked severe combined immunodeficiency (SCID‐X1, X‐SCID) is a life‐threatening disease caused by a mutated common cytokine receptor γ chain (γc) gene. Although __ex vivo__ gene therapy, i.e., transduction of the γc gene into autologous CD34^+^ cells, has been successfu