Comment on: Microsurgical Arterovenous Loops and Biological Templates: A Novel In Vivo Chamber for Tissue Engineering

✍ Scribed by Elias Polykandriotis; Andreas Arkudas; Justus Beier; Raymund E. Horch; Ulrich Kneser

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 70 KB
• Volume: 28
• Category: Article
• ISSN: 0738-1085
• DOI: 10.1002/micr.20467

✦ Synopsis

We congratulate the authors for an excellent article on the AV loop model. 1 We are pleased to see that the concept of intrinsic axial vascularization gains more and more acceptance. We concur with the authors that extracting quantitative results from experiments with this model is difficult because of the complexity of the model. The configuration of the venous graft (end-to-side) here is interesting and offers a useful option for future applications in reconstructive microsurgery since any vascular axis could be used for creation of the loop. This article stresses anew the fact that the arteriovenous interposing graft is participating significantly in the process of angiogenesis. This finding is in concordance with our results 2 as shown in three dimensional replicas of the AV loop itself and its arborisation (Fig. 1). We encourage the authors to introduce this technique in their modified AVloop model since it allows evaluating the angiogenetic response on a qualitative and quantitative base. It would be also interesting to test the vascular configuration of the authors in conjunction with vasoactive growth factors and porous matrices to see if the effects on the venous grafts are similar to the ''classic'' AV loop. 3,4