Comment on “Influence of βS-globin haplotypes and hydroxyurea on tumor necrosis factor-alpha levels in sickle cell anemia”✩✩See paper by Laurentino MR et al. on pages 121-5.

Influence of βS-globin haplotypes hydrox

Influence of βS-globin haplotypes hydroxyurea on tumor necrosis factor-alpha levels in sickle cell anemia

✍ Laurentino, Marília Rocha; Filho, Pedro Aurio Maia; Barbosa, Maritza Cavalcante; 📂 Article 📅 2014 🏛 SciELO 🌐 English ⚖ 197 KB

## Background Sickle cell anemia is a chronic inflammatory disease characterized by an increased production of proinflammatory cytokines including tumor necrosis factor-alpha. Hydroxyurea, by decreasing the polymerization of hemoglobin, reduces inflammatory states. The effect of the genetic polymor