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Comment on ‘increased frequency of combined methylenetetrahydrofolate reductase C677T and A1298C mutated alleles in spontaneously aborted embryos’

✍ Scribed by Isotalo, Phillip A; Donnelly, James G


Book ID
110025282
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
54 KB
Volume
10
Category
Article
ISSN
1018-4813

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Methylenetetrahydrofolate reductase (MTHFR) is involved in the one-carbon cycle, which is of importance for nucleotide synthesis and methylation of DNA, membranes, proteins and lipids. The MTHFR gene includes two common polymorphisms (rs1801133 or C677T; rs1801131 or A1298C) which both alter enzyme