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Comment on “A stationary-wave model of enzyme catalysis” by Carlo Canepa

✍ Scribed by Richard Lonsdale; Jeremy N. Harvey; Frederick R. Manby; Adrian J. Mulholland

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 46 KB
Volume: 32
Category: Article
ISSN: 0192-8651
DOI: 10.1002/jcc.21618

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✦ Synopsis

Abstract

Energy barriers for enzyme‐catalyzed reactions calculated with quantum mechanics/molecular mechanics (QM/MM) and empirical valence bond (EVB) methods can be in excellent agreement with activation energies derived from experiments, supporting the applicability of transition state theory for enzymic reactions. © 2010 Wiley Periodicals, Inc. J Comput Chem, 2011

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✍ Carlo Canepa 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 45 KB

## Abstract This letter briefly outlines the grounds that led to an expression for reaction rate co‐efficients based on the incomplete gamma function of Euler. The proposed law explains the catalytic activity of enzymes as an effect of the coupling of active vibrational modes to the reaction coordi