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Comment concerning “Childhood leukemia and residential magnetic fields: are pooled analyses more valid than the original studies?” (Bioelectromagnetics 27:1–7 [2006])

✍ Scribed by Leeka Kheifets; Gabor Mezei; Sander Greenland


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
43 KB
Volume
27
Category
Article
ISSN
0197-8462

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✦ Synopsis


Elwood [2006] contrasted the conclusions of three selected studies [Linet et al., 1997;McBride et al., 1999; UKCC, 1999] that there is no evidence for an association, to the positive findings of two pooled analyses by Ahlbom et al. [2000] and Greenland et al. [2000]. Elwood argued that these discrepancies may result from shortcomings of the pooled analyses, and suggested that the conclusions of the original studies may be more valid. While we agree that the issue of whether an effect is present remains far from settled, we believe that his analysis involves several conceptual and methodologic oversights which undermine his conclusion.


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Response to Kheifets et al. on “Comment
✍ J. Mark Elwood 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 40 KB 👁 1 views

diagnosis may more severely misrepresent historical exposure among cases than among controls, leading to bias; this bias would be downward if behavioral changes lead to lower exposure, and upward otherwise. Of the three studies chosen by Elwood, the McBride study (which showed the weakest associatio