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Commensal microbiota triggers spontaneous autoimmune encephalomyelitis

✍ Scribed by Berer, K.; Imaoka, A.; Umesaki, Y.; Johner, C.; Wekerle, H.; Krishnamoorthy, G.

Book ID
122224963
Publisher
Elsevier
Year
2014
Tongue
English
Weight
55 KB
Volume
20
Category
Article
ISSN
0941-9500

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## Abstract Transgenic mice with T‐cell receptor (TCR) specific for myelin basic protein (MBP)‐Ac1‐11 peptide and homozygous for the RAG‐1 mutation (T/Rβˆ’ mice) spontaneously develop acute progressive experimental autoimmune encephalomyelitis (Sp‐EAE) mediated by CD4+ T cells. Microarray analysis of