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Combretastatin Analogs via Hydration of Stilbene Derivatives

✍ Scribed by Mannila, Erkki ;Talvitie, Antti

Book ID: 102365371
Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 280 KB
Volume: 1993
Category: Article
ISSN: 0947-3440
DOI: 10.1002/jlac.1993199301165

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✦ Synopsis

Abstract

Hydration of the double bond of some stilbene congeners of Picea abies bark by TiCl~4~·NaBH~4~ reagent is described. Five racemic 1,2‐diphenylethanol derivatives (9–13), structurally related to (R)‐(·)‐combretastatin [(R)‐1], have been obtained and characterized mainly by ^13^C‐ and ^1^H‐NMR as well as mass spectrometry. The antileukemic activity of each compound has preliminarily been tested by the mouse leukemia L1210 system. Compound 10 has been synthesized by Friedel‐Crafts acylation.

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