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Combining proteasome inhibition with TNF-related apoptosis-inducing ligand (Apo2L/TRAIL) for cancer therapy

✍ Scribed by Thomas J. Sayers; William J. Murphy


Book ID
105967014
Publisher
Springer-Verlag
Year
2005
Tongue
English
Weight
342 KB
Volume
55
Category
Article
ISSN
0340-7004

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Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has received considerable attention as a potential anticancer agent. However, recombinant Apo2L/TRAIL has several limitations, which include a weak pharmacokinetic profile, namely, a short biological half-life and rapid renal clearance,