Combining particle size distribution and isothermal calorimetry data to determine the reaction kinetics of α-tricalcium phosphate–water mixtures
✍ Scribed by Marc Bohner; Anna K. Malsy; Christopher L. Camiré; Uwe Gbureck
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 219 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1742-7061
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✦ Synopsis
Many calcium phosphate bone substitutes are based on the use of a-tricalcium phosphate (a-TCP) powder. This compound has been intensively studied, but some aspects of a-TCP reactivity are still controversial. The goal of this study was to determine the setting kinetics of a-TCP based on a new approach that compared particle size distribution data to isothermal calorimetry data. Results indicated that a-TCP conversion is mostly controlled by surface reactions, with at later stages a diffusion-controlled mechanism. The presence of an X-ray amorphous a-TCP fraction in the crystalline a-TCP powder increased the dissolution rate threefold, without modifying the reaction mechanism.