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Combining mutations in HIV-1 reverse transcriptase with mutations in the HIV-1 polypurine tract affects RNase H cleavages involved in PPT utilization

✍ Scribed by Mary Jane McWilliams; John G. Julias; Stefan G. Sarafianos; W. Gregory Alvord; Eddy Arnold; Stephen H. Hughes


Book ID
113946728
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
519 KB
Volume
348
Category
Article
ISSN
0042-6822

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## Abstract Recent studies have highlighted the need of investigating the in vivo role of ribonuclease H (RNase H) in nucleoside reverse transcriptase inhibitors (NRTIs) resistance. The prevalence of RNase H mutations in naive and in NRTI pre‐treated patients in regimen failure were compared and so