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Combining Information from Similar Experiments: II. Quantifying Qualitative Results

✍ Scribed by Dr. J. S. Verducci

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 832 KB
Volume: 30
Category: Article
ISSN: 0323-3847
DOI: 10.1002/bimj.4710300403

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✦ Synopsis

Suppose that independent experiments each indicate general qualitative results, such as higher than normal incidence rates of tumors for exposed populations. This paper suggests methods for amalgamating the qualitative results from several such experiments into a more quantitative form, such as a dose-response relationship. The methods are designed to be robust both to systematic bias in one of the experiments and also to procedural variability across experiments. Data from four rodent experiments with tolaxamide are used to illustrate the methods.

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✍ Dr. J. S. Verducci 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 692 KB

A general method for combining information froin similar experiments is illustrated in the case where two independent experiments are designed to estimate a dose-response curve. By accounting for variability acrosa experiments, the proposed method avoids inferential pitfalls such as extended forms o