✦ LIBER ✦

Combining conditionally replicating adenovirus-mediated gene therapy with chemotherapy: A novel antitumor approach

✍ Scribed by Guan Jiang; Yong Xin; Jun-Nian Zheng; Yan-Qun Liu

Publisher: John Wiley and Sons
Year: 2011
Tongue: French
Weight: 304 KB
Volume: 129
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.25948

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Despite significant improvements in diagnosis and innovations in the therapy of specific cancers, effective treatment of neoplastic diseases still presents major challenges. Recent studies have shown that conditionally replicating adenoviruses (CRAds) not only have the ability to destroy cancer cells but may also be potential vectors for the expression of therapeutic genes. Several studies in animal models have demonstrated that the combination of CRAds‐mediated gene therapy and chemotherapy has greater therapeutic benefit than either treatment modality alone. In this review, an overview of specifications for a novel antitumor approach combining CRAd‐gene therapy and chemotherapy is provided and recent progress in this field is discussed.

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