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Combined use of mutant mice and classical pharmacology to characterise receptor functions: the case of dopamine D2 and D3 receptors

✍ Scribed by Ronan Depoortere

Publisher
Springer
Year
1999
Tongue
English
Weight
19 KB
Volume
147
Category
Article
ISSN
0033-3158

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Dystonia musculorum (dt J /dt J ) mutant mice suffer from a degeneration of spinocerebellar tracts as well as a dystrophy of peripheral sensory tracts. This neurological mutant has been proposed as an animal model of human cerebellar ataxia, in particular of the Friedreich's type; thus, it was deeme