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Combined use of immunohistochemistry and in situ hybridization for chromogranin A to detect small cell lung cancer with neuroendocrine features

Book ID
123408179
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
160 KB
Volume
11
Category
Article
ISSN
0169-5002

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Detection of chromogranin A mRNA in smal
Detection of chromogranin A mRNA in small cell lung carcinoma using a new, highly sensitive in Situ hybridization method with a non-radioisotope oligonucleotide probe
✍ Yoshiaki Sumiyoshi; Takayuki Shirakusa; Yuichi Yamashita; Takafumi Maekawa; Teru πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 285 KB πŸ‘ 2 views

## Background: Immunoreactivity for chromogranin a (cg a) is associated with the presence of neurosecretory granules in tumor cells, but immunohistochemical staining for cg a may be absent in small cell lung carcinoma (sclc), which has only a few secretory granules. localization of cg a mrna is a u

Detection of chromogranin A mRNA in smal
Detection of chromogranin A mRNA in small cell lung carcinoma using a new, highly sensitive in situ hybridization method with a non-radioisotope oligonucleotide probe
✍ AndrΓ© J. Balaton; Bernard A. Galet πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 33 KB πŸ‘ 2 views

W e read with great interest the article by Sumiyoshi et al., 1 in which the authors report that the detection of chromogranin A (Cg A) mRNA using a new in situ hybridization method is far more sensitive than immunohistochemistry. In their series, 100% of 20 small cell carcinoma (SCLC) cases were po