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Combined treatment with endothelin- and PAF-antagonists reduces posttransplant lung ischemia/reperfusion injury

✍ Scribed by Uz Stammberger; Giovanni L Carboni; Sven Hillinger; Dieter Schneiter; Walter Weder; Ralph A Schmid


Book ID
117711048
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
147 KB
Volume
18
Category
Article
ISSN
1557-3117

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This study investigated the effects of dual endothelin (ET) receptor blockade in rat models of liver ischemia and reperfusion injury (IRI). Three models of IRI were used: (1) in vivo total hepatic warm ischemia with portal shunting for 60 minutes with control (saline) and treatment groups (15 mg/kg