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Combined Technologies for Microfabricating Elastomeric Cardiac Tissue Engineering Scaffolds

✍ Scribed by Maxime D. Guillemette; Hyoungshin Park; James C. Hsiao; Saloni R. Jain; Benjamin L. Larson; Robert Langer; Lisa E. Freed

Book ID
102933892
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
949 KB
Volume
10
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

Polymer scaffolds that direct elongation and orientation of cultured cells can enable tissue engineered muscle to act as a mechanically functional unit. We combined micromolding and microablation technologies to create muscle tissue engineering scaffolds from the biodegradable elastomer poly(glycerol sebacate). These scaffolds exhibited well defined surface patterns and pores and robust elastomeric tensile mechanical properties. Cultured C2C12 muscle cells penetrated the pores to form spatially controlled engineered tissues. Scanning electron and confocal microscopy revealed muscle cell orientation in a preferential direction, parallel to micromolded gratings and long axes of microablated anisotropic pores, with significant individual and interactive effects of gratings and pore design.

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