✦ LIBER ✦

Combined phentermine/fenfluramine administration enhances depletion of serotonin from central terminal fields

✍ Scribed by Robert Lew; Brian Weisenberg; Georgetta Vosmer; Lewis S. Seiden

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 268 KB
Volume: 26
Category: Article
ISSN: 0887-4476
DOI: 10.1002/(sici)1098-2396(199705)26:1<36::aid-syn4>3.0.co;2-f

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✦ Synopsis

Administration of phentermine (Phen) together with ( 6) fenfluramine (Fen) enhances the weight reduction that is observed with either drug alone; consequently, these anorectic agents are commonly prescribed together for weight reduction. Repeated administration of Fen is known to cause long-term depletion of axonal serotonin (5-HT) and loss of 5-HT transporters, and is therefore considered neurotoxic.