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Combined mobilization and stimulation of tumor-infiltrating dendritic cells and natural killer cells with Flt3 ligand and IL-18 in vivo induces systemic antitumor immunity

✍ Scribed by Tetsuya Saito; Takuya Takayama; Tadashi Osaki; Shigenori Nagai; Toshihiro Suzuki; Marimo Sato; Hiroyuki Kuwano; Hideaki Tahara

Book ID: 108584288
Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 595 KB
Volume: 99
Category: Article
ISSN: 1347-9032
DOI: 10.1111/j.1349-7006.2008.00907.x

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## Abstract ## Background Tumor antigen presentation by dendritic cells (DCs) to T cells in lymphoid organs is crucial for induction of antitumor immune responses. Fms‐like tyrosine kinase 3 ligand (Flt3L) is a regulator of hematopoietic cell development. ## Methods To investigate the potential