COMBINED MANAGEMENT OF MALIGNANT TERATOMA OF THE TESTIS

✍ Scribed by Peckham, M.J; Barrett, A; Mcelwain, T.J; Hendry, W.F

• Book ID: 122513908
• Publisher: The Lancet
• Year: 1979
• Tongue: English
• Weight: 453 KB
• Volume: 314
• Category: Article
• ISSN: 0140-6736
• DOI: 10.1016/S0140-6736(79)90288-5

✦ Synopsis

Intensive chemotherapy with bleomycin and vinblastine was used as initial treatment in patients with advanced testicular teratoma and after relapse following lymph-node irradiation in pa- tients with early-stage disease. Between January, 1976, and March, 1978, 84 patients, 28 with early disease and 56 with advanced disease, were treated. All 28 men with early-stage disease are alive and disease-free. Patients with advanced disease were divided into two groups. Patients with bulky multiple lung metastases and those with liver involvement did poorly, only 4 of 23 (17·4%) being disease-free. Conversely, patients with bulky ab- dominal nodes and those with limited lung disease did well, 17 of 21 previously untreated patients (80·9%) being alive and disease-free. Within the latter group, 16 patients were managed with chemotherapy and radio- therapy and/or surgery. Of these, 15 (93·*4%) are disease-free.