Combined LOH/CGH analysis proves the existence of interstitial 3p deletions in renal cell carcinoma

Major role for a 3p21 region and lack of

Major role for a 3p21 region and lack of involvement of the t(3;8) breakpoint region in the development of renal cell carcinoma suggested by loss of heterozygosity analysis

✍ Anke van den Berg; Miriam M. F. Hulsbeek; Debora de Jong; Klaas Kok; Patrick M. 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 792 KB

In a loss of heterozygosity analysis of 3p, we examined 44 sporadic cases of renal cell carcinoma (RCC) and matched normal tissue with 18 markers distributed over the whole p-arm. The majority of these markers clustered in three regions that have been suggested t o be involved in the development of