Between January 1969, and August 1975, 40 patients with pathologic Stage I1 carcinoma of the endometrium were treated at the Joint Center for Radiation Therapy. The treatment policy included external and intracavitary irradiation combined with surgery. The majority of patients received 4000 mglhours of radium exposure using a Fletcher-Suit applicator and 4000 rad whole pelvis external irradiation, followed by hysterectomy and bilateral salpingooophorectomy. Median age of the patients was 61 years (39-88) and the median followup of the patients still alive was 69 months (29-102). Relapse-free 5-year survival corrected for intercurrent disease was 83% and uncorrected, 78%. Overall survival was 80%. Five patients had relapsing disease, three patients failed at distant sites only, one patient died of treatment related complications, and two failed locally and distantly. There were no failures in the pelvis alone. Although the relationship between histologic grade and failure is not statistically significant, there were four failures among the 12 Grade I11 patients compared to two failures in 27 with Grades I and 11. Similarly, 4 of 12 patients with gross cervical involvement developed relapsing disease, but only 2 of 28 failed with microscopic cervical involvement. This treatment policy yields excellent survival and continues to be our treatment recommendation.
Cancer 42:1146-1151, 1978. XTENSION OF ENDOMETRIAL CARCINOMA E to the cervix (FIG0 Stage IQ8 has traditionally connoted a poor prognosis. Kottmeier summarized the results from 52 institutions reporting a 5-year survival of 70% for patients with Stage I disease and 47.4% for patients with Stage I1 d i s e a ~e . ~ Another review combining results for 1860 Stage I patients and 205 Stage I1 patients reported 5-year survival figures of 76% and 5 1 %, re~pective1y.l~ The treatment method in these reports varied, and included radical hysterectomy with lymph node dissection, radical radiation therapy alone, and combination of radiation therapy and surgery.