Combined hyperthermia and chlorophyll-based photodynamic therapy: tumour growth and metabolic microenvironment

Intensified oxidative and nitrosative st

Intensified oxidative and nitrosative stress following combined ALA-based photodynamic therapy and local hyperthermia in rat tumors

✍ Juergen Frank; Christine Lambert; Hans Konrad Biesalski; Oliver Thews; Peter Vau 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 312 KB

## Abstract Oxidative stress‐related changes in tumors upon localized hyperthermia (HT), 5‐aminolevulinic acid‐based photodynamic therapy (ALA‐PDT) and their combination (ALA+HT) were examined after the observation that the antitumor effects of ALA‐PDT could be significantly enhanced upon simultane