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Combined effects of temozolomide and the ribonucleotide reductase inhibitors didox and trimidox in malignant brain tumor cells

✍ Scribed by M. Figul; A. Söling; H. J. Dong; T.-C. Chou; N. G. Rainov


Book ID
105991786
Publisher
Springer
Year
2003
Tongue
English
Weight
249 KB
Volume
52
Category
Article
ISSN
0344-5704

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Upon appropriate drug treatment, the human erythroleukemic K562 cells have been shown to produce hemoglobin and F-cells. Fetal hemoglobin (Hb F) inhibits the polymerization events of sickle hemoglobin (Hb S), thereby ameliorating the clinical symptoms of sickle cell disease. Ribonucleotide reductase