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Combined effects of prostaglandin E receptor subtype EP1 and subtype EP4 antagonists on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice

✍ Scribed by Tomohiro Kitamura; Masaki Itoh; Tetsuo Noda; Kousuke Tani; Michiyoshi Kobayashi; Takayuki Maruyama; Kaoru Kobayashi; Shuichi Ohuchida; Takashi Sugimura; Keiji Wakabayashi

Book ID
108582316
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
112 KB
Volume
94
Category
Article
ISSN
1347-9032

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Combined effects of cyclooxygenase-1 and
Combined effects of cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice
✍ Tomohiro Kitamura; Masaki Itoh; Tetsuo Noda; Mamoru Matsuura; Keiji Wakabayashi πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 French βš– 88 KB

## Abstract As with cyclooxygenase (COX)‐2, genetic disruption of __COX‐1__ gene or pharmacologic inhibition of its activity has been shown to decrease the number of intestinal polyps in __Apc__ gene‐deficient mice. The present study was designed to investigate the combined effects of COX‐1 and COX