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Combined Effects of Polymorphisms of DNA-repair Protein Genes and Metabolic Enzyme Genes on the Risk of Cholangiocarcinoma

โœ Scribed by Zeng, L.; You, G.; Tanaka, H.; Srivatanakul, P.; Ohta, E.; Viwatthanasittiphong, C.; Matharit, M.; Chenvidhya, D.; Jedpiyawongse, A.; Tanaka, M.; Fujii, T.; Sripa, B.; Ohshima, K.; Miwa, M.; Honjo, S.

Book ID
121390232
Publisher
Oxford University Press
Year
2013
Tongue
English
Weight
102 KB
Volume
43
Category
Article
ISSN
0368-2811

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## Abstract Rates of adenocarcinoma of the esophagus (EAC) and esophagoโ€gastric junction (EGJAC) have increased rapidly in recent decades. The primary risk factors, gastroโ€esophageal acid reflux and smoking, are potentially genotoxic through the generation of __N__โ€nitroso compounds. The DNA repair