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Combined effects of GSTO1 and SULT1A1 polymorphisms and cigarette smoking on urothelial carcinoma risk in a Taiwanese population

โœ Scribed by Tung, Min-Che; Wang, Yuan-Hung; Yeh, Shauh-Der; Wu, Chia-Chang; Chen, Kuan-Chou; Huang, Zhon-Min; Huang, Ming-Te; Chiou, Hung-Yi


Book ID
123218681
Publisher
Chinese Electronic Periodical Services
Year
2014
Tongue
English
Weight
290 KB
Volume
113
Category
Article
ISSN
0929-6646

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## Abstract Cigarette smoke contains polycyclic hydrocarbons and arylamines that may both be activated by sulfotransferase, encoded by __SULT1A1__. A genetic polymorphism leads to an Arg213His substitution, thereby decreasing enzyme activity and stability and might thus modify the association betwe