Combined effects of chronic audio-visual stress and thiouracil administration on the cholesterol-fed rat
✍ Scribed by Anderson, Thomas A. ;Geber, William F.
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1965
- Tongue
- English
- Weight
- 409 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0095-9898
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✦ Synopsis
Weanling Sprague-Dawley rats fed a standard laboratory diet containing 2% cholesterol and 1% sodium cholate, when exposed to audio-visual stress for a three-week period, were found to have significantly heavier thyroids, lighter livers, higher serum cholesterol and increased adrenal ascorbic acid levels than similarly treated control animals. The addition of thiouracil to the ration (0.25% and 0 . 5 0 % ) produced the expected increases in liver and thyroid weight and serum cholesterol. Thiouracil administration also caused a marked depression in adrenal weight and adrenal ascorbic acid levels. A significant stress X diet interaction was noted on thyroid weight, suggesting that stress and diet were not independent of each other in their influence on the thyroid. The combined effects of chronic audio-visual stress and thiouracil administration had essentially no effect on total hepatic or adrenal cholesterol levels.