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Combined cyclophosphamide, vincristine, and prednisone therapy of malignant lymphoma

✍ Scribed by James K. Luce; Jess F. Gamble; Henry E. Wilson; Raymond W. Monto; Bertha L. Isaacs; Robert L. Palmer; Charles A. Coltman Jr.; James S. Hewlett; Edmund A. Gehan; Emil Frei III

Publisher
John Wiley and Sons
Year
1971
Tongue
English
Weight
914 KB
Volume
28
Category
Article
ISSN
0008-543X

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✦ Synopsis

A combination of intravenous cyclophosphamide and vincristine (Oncovin) and oral prednisone (COP) was given every 2 weeks to 262 patients with disseminated Hodgkin's disease, lymphosarcoma, reticulum cell sarcoma, a n d follicular lymphoma. A complete remission was produced in 36% of patients with Hodgkin's disease, 50% of patients with lymphosarcoma, and 39% of patients with reticulum cell sarcoma. These remission rates are significantly superior to those produced by single agents. Patients who achieved a complete remission were randomly allocated to monthly COP (maintained remission) or to no treatment (unmaintained remission). T h e median duration of maintained remission was longer than unmaintained remission for Hodgkin's disease

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## Abstract In stage IV non‐Hodgkin's lymphomas, CVP (cyclophosphamide, vincristine, and prednisone) was randomly compared to ABP (adriamycin, bleomycin, and prednisone). Of 62 patients entered into the study, 57 (CVP 27, ABP 30) were considered evaluable for comparison. In patients with liver and/