Influenza viruses attach to susceptible cells via multivalent interactions of their haemagglutinins with sialyloligosaccharide moieties of cellular glycoconjugates. Soluble macromolecules containing sialic acid from animal sera and mucosal fluids can act as decoy receptors and competitively inhibit
Combined Anti-influenza Virus Effect of Natural and Synthetic Viral Inhibitors
β Scribed by Julia Serkedjieva; Iskra Ivanova
- Book ID
- 113458567
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 66 KB
- Volume
- 90
- Category
- Article
- ISSN
- 0166-3542
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Structure-based design and synthesis of potent influenza virus neuraminidase inhibitors are now being evaluated in human trials as anti-influenza virus drugs. The first drug of this class, Relenzaβ’ (Zanamivir/GG167), is now awaiting pharmaceutical evaluation and registration in Australia, Europe, an
When certain compounds-mostly antimetabolites inhibitory to influenza virus replication in tissue culture-were combined in various ways, the virus inhibition was enhanced in a s nergistic manner with many o f the combinations studied. The selectivit of this ingibitory effect also was increased signi