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Combine therapy of gefitinib and fulvestrant enhances antitumor effects on NSCLC cell lines with acquired resistance to gefitinib

✍ Scribed by Ruitong Xu; Hua Shen; Renhua Guo; Jing Sun; Wen Gao; Yongqian Shu


Book ID
119196190
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
717 KB
Volume
66
Category
Article
ISSN
0753-3322

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## Abstract Activation of the epidermal growth factor receptor (EGFR) contributes to the pathogenesis of non‐small‐cell lung carcinomas (NSCLC) and gefitinib, a selective reversible EGFR inhibitor, is effective in treating patients with NSCLC. However, clinical resistance to gefitinib is a frequent