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Combinatorial Synthesis of New Cationic Lipids and High-Throughput Screening of Their Transfection Properties

✍ Scribed by Karl Lenssen; Peter Jantscheff; Günter von Kiedrowski; Ulrich Massing


Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
168 KB
Volume
3
Category
Article
ISSN
1439-4227

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Synthesis and Transfection Activity of N
✍ Mathieu Mével; Gilles Breuzard; Jean-Jacques Yaouanc; Jean-Claude Clément; Pierr 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 381 KB

## Abstract In an effort to enhance the gene‐transfer efficiencies of cationic lipids and to decrease their toxicities, a series of new phosphoramidate lipids with chemical similarity to cell membrane phospholipids was synthesised. These lipids contained various cationic headgroups, such as arginin