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Combinatorial code of growth factors and neuropeptides define neuroendocrine differentiation in PC12 cells

✍ Scribed by Delphine Beaujean; Claudia Rosenbaum; Hans-Werner Müller; Jacques J Willemsen; Jacques Lenders; Stefan R Bornstein


Book ID
116458118
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
473 KB
Volume
184
Category
Article
ISSN
0014-4886

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The lipid biomediator lysophosphatidic acid (LPA) elicits a unique response in hippocampal neurons, LPA induces neuronal apoptosis. This study explores the effects of LPA on cells with neuronal properties, nerve growth factor-differentiated PC6 cells, a clone of PC12 cells. LPA induced apoptosis in