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Combination treatments with ABT-263 and an immunotoxin produce synergistic killing of ABT-263-resistant small cell lung cancer cell lines

โœ Scribed by Abid R. Mattoo; David J. Fitzgerald


Book ID
115556512
Publisher
John Wiley and Sons
Year
2012
Tongue
French
Weight
637 KB
Volume
132
Category
Article
ISSN
0020-7136

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## Purpose Resistance to chemotherapy-induced apoptosis represents a major obstacle to cancer control. Overexpression of Bcl-2 is seen in multiple tumor types and targeting Bcl-2 may provide therapeutic benefit. A phase I study of navitoclax, a novel inhibitor of Bcl-2 family proteins, was conduct