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Combination Treatment with Resveratrol and Sulforaphane Induces Apoptosis in Human U251 Glioma Cells

โœ Scribed by Hao Jiang; Xia Shang; Hongtao Wu; Grace Huang; Yiyang Wang; Shaza Al-Holou; Subhash C. Gautam; Michael Chopp

Publisher
Springer
Year
2009
Tongue
English
Weight
429 KB
Volume
35
Category
Article
ISSN
0364-3190

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## Abstract Geldanamycin (GA) binds to heat shock protein 90 (Hsp90) and interferes with its function which is to protect various cellular proteins involved in signaling, growth control, and survival from ubiquitination and subsequent degradation by the proteasome. Recently, we demonstrated that GA