Combination treatment of nitrosamiee-induced pancreatic cancers in hamsters with analogs of LH-RH and a bombesin/GRP antagonist

Effect of combination treatment with ana

Effect of combination treatment with analogs of luteinizing hormone-releasing hormone (LH-RH) or somatostatin and 5-fluorouracil on pancreatic cancer in hamsters

✍ Karoly Szepeshazi; Karoly Lapis; Andrew V. Schally 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 905 KB

Ductal pancreatic cancers were induced with N-nitrosobis(2-oxopropyl)amine (BOP) in female Syrian golden hamsters. The animals were then treated for 2 months with 5-fluorouracil (5-FU) and with sustained delivery systems of the LH-RH a Onist 'D-Trp-6-LH-RH antagonist (Ac-D-Nal(2)'-D-Phe(~CI)~-D-Pal(