Combination therapy of murine liver cancer with il-12 gene and HSV-TK gene
β Scribed by Zhan-yun Tang; Wen-chang Sun; Shi-shu Chen
- Book ID
- 105675825
- Publisher
- Chinese Anti-Cancer Association
- Year
- 2000
- Tongue
- English
- Weight
- 356 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1000-9604
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π SIMILAR VOLUMES
Tumor cells genetically modified with the herpes simplex virus thymidine kinase (HSV-tk) gene in combination with ganciclovir (GCV) demonstrate a ''bystander effect''. Previous attempts to enhance the bystander tumor killing by combining cytokine genes with HSV-tk/GCV have met with varying results.
## Abstract ## Background The present study aimed to evaluate the antitumor effectiveness of systemic __interleukin (IL)β12__ gene therapy in murine sarcoma models, and to evaluate its interaction with the irradiation of tumors and metastases. To avoid toxic sideβeffects of __ILβ12__ gene therapy,