Combination Self-Assembly of β-Sheet Peptides and Carbon Nanotubes: Functionalizing Carbon Nanotubes with Bioactive β-Sheet Block Copolypeptides

✍ Scribed by Woo-jin Jeong; Yong-beom Lim

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 439 KB
• Volume: 12
• Category: Article
• ISSN: 1616-5187
• DOI: 10.1002/mabi.201100284

✦ Synopsis

Abstract

Understanding the self‐assembly behavior of β‐sheet peptides is important, not only in constructing bioactive peptide nanostructures, but also in inhibiting uncontrollable protein aggregation in protein‐misfolding diseases. Here, the first systematic investigation of combination self‐assembly between β‐sheet block copolypeptides and CNTs is presented, demonstrating the presence of several different association modes during the combination self‐assembly process. Bioactive β‐sheet block copolypeptides can self‐assemble by themselves, or can be used to functionalize CNT hybrids depending on the situation. This behavior may be important both for fabricating bioactive peptide/CNT hybrids and for controlling/inhibiting protein‐misfolding diseases.magnified image