Combination of Vitamin E with a Carotenoid: α-Tocopherol and Trolox Linked to β-Apo-8′-carotenoic Acid

✍ Scribed by Eva Larsen; Jan Abendroth; Vassilia Partali; Bernhard Schulz; Hans-Richard Sliwka; Edward G. K. Quartey

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 132 KB
• Volume: 4
• Category: Article
• ISSN: 0947-6539
• DOI: 10.1002/(sici)1521-3765(199801)4:1<113::aid-chem113>3.0.co;2-q

✦ Synopsis

Vitamin E and carotenoids show many similar and complementary properties and protect living tissues against a variety of pathological processes. A mixture of both compounds often exhibits a significantly greater effect than the sum of the individual activities. The synthetic linkage of carotenoids with vitamin E might thus increase the synergistic effects. We therefore esterified b-apo-8'-carotenoic acid with all-rac-a-tocopherol to give atocopheryl-b-apo-8'-carotenoate. The carotenoic acid was also connected to a-tocopherol in a glyceride ether, 1-O-(a-tocopheryl)-3-(b-apo-8'-carotenoyl)glycerol, whereas the water-soluble vitamin E analogue, trolox, was combined with b-apo-8'-carotenoic acid in a diglyceride: 1-(6-hydroxy-2,5,7,8-tetramethylchroman-2-acyl)-3-(b-apo-8'-carotenoyl)-glycerol.