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Combination of somatostatin analogues and dexamethasone (antisurvival-factor concept) with luteinizing hormone-releasing hormone in androgen ablation-refractory prostate cancer with bone metastasis

✍ Scribed by Michael Koutsilieris; Theodore Dimopoulos; Constantine Milathianakis; John Bogdanos; Dimitrios Karamanolakis; Nicholas Pissimissis; Antonis Halapas; Peter Lembessis; Andreas Papaioannou; Antigone Sourla

Book ID: 109053329
Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 74 KB
Volume: 100
Category: Article
ISSN: 1464-4096
DOI: 10.1111/j.1464-410x.2007.06958.x

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## BACKGROUND. Osteoblasts and osteoblast-derived survival growth factors, such as insulin-like growth factor I (IGF I), inhibit chemotherapy apoptosis of prostate cancer cells, thereby producing cytotoxic drug-resistant tumor growth, in vitro. METHODS. We tested a novel therapeutic approach, refe