Combination of hyperthermia (HT) and chemotherapy (CT) for hepatic tumors (HT) a phase I study
โ Scribed by Tsamas, A.; diPalma, M.; Adam, R.; Ionescu-Goga, M.; Magi, M.; Rotarski, M.; Sidi, J.; Vannetzel, J.M.; Bismuth, M.; Jasmin, C.
- Book ID
- 122404240
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 164 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0959-8049
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In a phase I study of BRL43694A, a 5HT3-receptor antagonist, a single dose of 40 micrograms/kg was given to 24 patients. All patients received cytostatic treatment expected to cause nausea and vomiting. During the first 24 h, 12 patients were completely protected from nausea and vomiting, 4 experien
## Abstract ## BACKGROUND The authors attempted to determine the maximum tolerated dose (MTD) of gemcitabine in combination with etoposide and cisplatin as a chemotherapy regimen and investigated the safety and antitumor activity with the recommended doses of gemcitabine with etoposide and cisplat