with complete responses were given an additional course of chemotherapy (intra-School of Medicine, Nagasaki, Japan. arterial cisplatin and doxorubicin) and irradiation (20 Gy), and patients with resid-
Combination of chemotherapy with dual antagonists and radiotherapy in the treatment of neoplastic disease
โ Scribed by Thomas J. Bardos; Julian L. Ambrus; Clara M. Ambrus
- Publisher
- John Wiley and Sons
- Year
- 1971
- Tongue
- English
- Weight
- 593 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0022-4790
No coin nor oath required. For personal study only.
โฆ Synopsis
The theoretical justification for combination chemotherapy and for the combination of radiation and chemotherapy in the treatment of neoplastic diseases is discussed. Literature on the synthesis and biological activity of the 'dual antagonist' group of drugs is reviewed, Studies on the radiation-potentiating effect of certain members of this group of drugs are reviewed, and prospects for therapeutic applications are discussed.
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A retrospective analysis of 46 histologically proven cases of neuroblastoma is presented. The over-all 2-year survival was 46%. All except 1 of the 21 patients surviving 2 years were continuously free of clinical and laboratory evidence of neuroblastoma. The patients treated before 1967 were treated