Combination of anorganic bovine-derived hydroxyapatite with binding peptide does not enhance bone healing in a critical-size defect in a rabbit model
✍ Scribed by Kambiz Sarahrudi; Mehdi Mousavi; Karl Grossschmidt; Nezir Sela; Franz König; Vilmos Vécsei; Seyedhossein Aharinejad
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 170 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0736-0266
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Anorganic bovine‐derived hydroxyapatite (ABM) in combination with binding peptid (P‐15) has demonstrated the capacity to improve the healing of periodontal defects. This study evaluated the benefit of ABM/P‐15 to promote healing of cortical long bone defects in a rabbit model. A 5‐mm segmental bone defect was created in the femur and fixed with a plate. There were two treatment groups: no implant (n = 12) and ABM/P‐15 (n = 12). At 4, 8, and 12 weeks, healing of the defect was evaluated with radiographs and histomorphometric examination of the treated femora. After 4 weeks, radiographs showed bone formation without signs of complete consolidation in three of four animals in the control group and two of four ABM/P‐15 treated animals. At the later course of the treatment, no radiologic difference was evident between the treatment groups. Histomorphometric evaluation revealed an area of 1.29 ± 0.11 mm^2^ and 0.97 ± 0.21 mm^2^ of newly produced bone in animals of the control group and ABM/P‐15 group after 4 weeks. After 8 and 12 weeks, animals in the control group had an area of 2.44 ± 0.62 mm^2^ and 2.5 ± 0.2 mm^2^ of newly produced bone within the osteotomy gap compared to 1.6 ± 0.65 mm^2^ and 1.56 ± 0.27 mm^2^ in the ABM/P‐15 group (p = 0.0004). An enhanced or accelerated ingrowth of bone, as reported in previous studies, was not observed. Our results imply that the ABM/P‐15 is not a suitable graft for the treatment of critical‐sized segmental defects in long bones. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 26:759–763, 2008