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Combination chemotherapy with cyclophosphamide, mitoxantrone and 5-fluorouracil in patients with metastatic breast cancer

โœ Scribed by Yap, H.Y.; Esparza, L.; Blumenschein, G.R.; Hortobagyi, G.N.; Bodey, G.P.


Book ID
123150394
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
196 KB
Volume
10
Category
Article
ISSN
0305-7372

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Combination chemotherapy for metastatic
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Twenty-nine patients with metastatic breast cancer were treated with fluorouracil, adriamycin, cyclophosphamide (FAC), and methotrexate (MTX), with or without leukovorin rescue. Of 24 evaluable patients, one achieved a complete remission and 17 had partial responses. The overall objective response r

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In this study, 30 evaluable patients with advanced carcinoma of the breast were treated with cyclophosphamide 600 mg/m2 i.v. followed one day later with mitoxantrone (Novantrone; dihydroxyanthracenedione) 16 mg/m2 i.v. Drug treatment was repeated every 3-4 weeks, for a maximum of 12 cycles. The over