✦ LIBER ✦

Combination chemotherapy in murine neuroblastoma

✍ Scribed by Finklestein, J. Z. ;Tittle, K. ;Rubenstein, J. ;Meshnik, R. ;Weiner, J.

Publisher: John Wiley and Sons
Year: 1976
Tongue: English
Weight: 539 KB
Volume: 2
Category: Article
ISSN: 0098-1532
DOI: 10.1002/mpo.2950020309

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The C1300 murine neuroblastoma system has been studied to determine its relevance as a chemotherapy model to the human disease. Studies using combination therapy revealed that BCNU/cyclophosphamide combination therapy increased the median lifespan 300% in A/J mice bearing the C1300 tumor. Cyclophosphamide/imidazole carboxamide and adriamycin/imidazole carboxamide combinations were less active, increasing median lifespans 189% and 144%, respectively. Vincristine/bleomycin were inactive even when the schedule was adjusted to coincide with the time of maximum mitoses following vincristine injections. These results suggest the BCNU/cyclophosphamide combination chemotherapy may be effective in human disease.

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